Plasmonic nanorainbow for label-free biomolecule sensing

A gold nanowire array that we call nanorainbow SPR sensor array can be chemically functionalized and used to capture biomolecules. The localized plasmon resonance wavelength of the gold nanowires shifts on the biomolecule binding and reaction sites. The plasmon resonance shift of the gold nanorainbow is sensitive to the biomolecule immobilization in sub-nM concentration. As an application example, label-free oligonucleotide hybridizations are detected on the nanorainbow sensor in a multiplexed microfluidic chip.

一种我们称之为纳米彩虹表面等离子体共振（SPR）传感器阵列的金纳米线阵列可以进行化学功能化，并用于捕获生物分子。金纳米线的局域等离子体共振波长会在生物分子结合和反应位点处发生偏移。金纳米彩虹的等离子体共振偏移对亚纳摩尔浓度的生物分子固定化很敏感。作为一个应用实例，在一个多路复用微流控芯片中的纳米彩虹传感器上检测到了无标记的寡核苷酸杂交。