Preparation and Properties of Poly(amidoamine) Dendrimer/Quaternary Ammonium Chitosan Hydrogels

A novel quaternary ammonium chitosan hydrogel modified by poly(amidoamine) (PAMAM) dendrimer was prepared by using glutaraldehyde as a cross-linker. The hydrogel was characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The results confirmed its highly porous three-dimensional network structure. The swelling test of hydrogel proved that it had excellent swelling and pH-sensitive properties. The increasing PAMAM content or quaternization degree led to the increase in swelling properties. And the hydrogel with lower cross-linking agent concentration or quaternary ammonium chitosan concentration exhibited better swelling properties. The antibacterial results indicated that with the increase in the PAMAM content, quaternary ammonium chitosan concentration or cross-linking agent concentration, the hydrogels showed better antibacterial activities against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Thus, the hydrogel could serve as a promising antibacterial material in the future.

以戊二醛为交联剂制备了一种经聚酰胺 - 胺（PAMAM）树枝状大分子改性的新型季铵化壳聚糖水凝胶。通过傅里叶变换红外光谱（FTIR）和扫描电子显微镜（SEM）对水凝胶进行了表征。结果证实其具有高度多孔的三维网络结构。水凝胶的溶胀试验证明它具有优异的溶胀性能和pH敏感特性。PAMAM含量或季铵化程度的增加导致溶胀性能提高。交联剂浓度或季铵化壳聚糖浓度较低的水凝胶表现出更好的溶胀性能。抗菌结果表明，随着PAMAM含量、季铵化壳聚糖浓度或交联剂浓度的增加，水凝胶对金黄色葡萄球菌（S. aureus）和大肠杆菌（E. coli）均表现出更好的抗菌活性。因此，该水凝胶在未来可作为一种有前景的抗菌材料。