Hyaluronic acid-coated ZIF-8 for the treatment of pneumonia caused by methicillin-resistant Staphylococcus aureus

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common causes of hospital infection. Here, we showed that hyaluronic acid modified organic metal framework material ZIF-8 could be a Trojan horse of vancomycin (Van) for effective treatment of MRSA infections. The Van-loaded nanoparticles were readily up-taken by macrophages via a CD44-mediated process and collapsed in the acidic condition of endosome/lysosome, as a consequence, it could eradicate MRSA with high efficiency in macrophages. This drug delivery system with negligible toxicity could resolve MRSA infections in a well-established mouse pneumonia model. (C) 2020 Elsevier B.V. All rights reserved.

耐甲氧西林金黄色葡萄球菌（MRSA）是医院感染最常见的病因之一。在此，我们表明透明质酸修饰的有机金属框架材料ZIF - 8可作为万古霉素（Van）的“特洛伊木马”，用于有效治疗MRSA感染。载有万古霉素的纳米颗粒可通过CD44介导的过程轻易地被巨噬细胞摄取，并在内体/溶酶体的酸性条件下崩解，因此，它可高效清除巨噬细胞中的MRSA。这种毒性可忽略不计的药物递送系统能够在一个成熟的小鼠肺炎模型中解决MRSA感染问题。（C）2020爱思唯尔公司。版权所有。