No association between 5 new GWAS-linked loci in Parkinson's disease and multiple system atrophy in a Chinese population

Recently, 17 new Parkinson's disease (PD) risk loci were identified in a genome-wide association studies meta-analysis in Caucasians; however, their association with PD in Chinese patients is largely unknown. Therefore, we performed a replication study of 5 of the most commonly identified candidate variants, including SORBS3 rs2280104, SCN3A rs353116, TOX3 rs4784227, GLAC rs8005172, and ZNF184 rs9468199, in a large sample of patients with PD (1506) and multiple system atrophy (MSA, 496) in a Chinese population. These 5 variants were found to not be associated with PD and MSA in the Chinese population. Our results suggest that these variants are not risk factors for PD or MSA in the Chinese population. (C) 2018 Elsevier Inc. All rights reserved.

最近，在对白种人的全基因组关联研究荟萃分析中确定了17个新的帕金森病（PD）风险位点；然而，它们与中国患者帕金森病的关联在很大程度上是未知的。因此，我们在中国人群的大量帕金森病患者（1506例）和多系统萎缩（MSA，496例）样本中，对5个最常被确定的候选变异体进行了重复研究，包括SORBS3 rs2280104、SCN3A rs353116、TOX3 rs4784227、GLAC rs8005172和ZNF184 rs9468199。发现这5个变异体与中国人群的帕金森病和多系统萎缩无关。我们的研究结果表明，这些变异体不是中国人群帕金森病或多系统萎缩的风险因素。（C）2018爱思唯尔公司。保留所有权利。