Interaction of obesity and central obesity on elevated urinary albumin-to-creatinine ratio.

Microalbuminuria was much more common among obese individuals indicating a probable association with obesity. However, association of microalbuminuria with interaction between obesity and central obesity has not yet been studied. A cross-sectional study was conducted in a 2889 general population aged ≥30 years. Obesity was defined as body mass index ≥28.0 kg/m2 and central obesity was defined as waist-to-hip ratio ≥0.85 for females and ≥0.90 for males. Both additive and multipliable interactions between obesity and central obesity on elevated urinary albumin-to-creatinine ratio (UACR) were evaluated. After controlling for potential covariates, participants with both obesity and central obesity have significantly increased risk for elevated UACR (OR = 1.82 P<0.001) compared to those with neither. Additive interaction analysis indicated that about 43.9% of the risk of elevated UACR in participants with both obesity and central obesity was attributed to the interaction between obesity and central obesity (the attributable proportion because of the interaction: 0.439; 95% CI: 0.110–0.768). The multipliable interactive effect between obesity and central obesity on elevated UACR was not found significant (OR = 1.82, P = 0.078). Microalbuminuria was significantly associated with the interaction between obesity and central obesity. Our results indicated that individuals with both obesity and central obesity should be intensively managed to prevent renal diseases.

微量白蛋白尿在肥胖个体中更为常见，这表明它可能与肥胖有关。然而，微量白蛋白尿与肥胖和中心性肥胖之间相互作用的关联尚未得到研究。 在年龄≥30岁的2889名普通人群中进行了一项横断面研究。肥胖定义为体重指数≥28.0 kg/m²，中心性肥胖定义为女性腰臀比≥0.85，男性腰臀比≥0.90。评估了肥胖和中心性肥胖对尿白蛋白 - 肌酐比值（UACR）升高的相加和相乘相互作用。 在控制了潜在的混杂因素后，与既不肥胖也无中心性肥胖的参与者相比，同时患有肥胖和中心性肥胖的参与者UACR升高的风险显著增加（比值比 = 1.82，P < 0.001）。相加相互作用分析表明，同时患有肥胖和中心性肥胖的参与者中UACR升高的风险约43.9%归因于肥胖和中心性肥胖之间的相互作用（归因于相互作用的比例：0.439；95%置信区间：0.110 - 0.768）。肥胖和中心性肥胖对UACR升高的相乘相互作用效应未发现有统计学意义（比值比 = 1.82，P = 0.078）。 微量白蛋白尿与肥胖和中心性肥胖之间的相互作用显著相关。我们的研究结果表明，同时患有肥胖和中心性肥胖的个体应得到强化管理以预防肾脏疾病。