TIPE1 Inhibits Breast Cancer Proliferation by Downregulating ERK Phosphorylation and Predicts a Favorable Prognosis

TIPE1, which acts as a cell death regulator, has emerged as a tumor suppressor in the process of carcinogenesis. However, our recent research demonstrated that it serves as an oncogene in the pathogenesis of cervical cancer, indicating that the role of TIPE1 in carcinogenesis needs to be further evaluated. In this study, we show that TIPE1 is able to inhibit breast cancer cell growth both in vivo and in vitro. Functionally, TIPE1 inhibits cancer cell proliferation preferentially by downregulating ERK phosphorylation. Furthermore, the expression of TIPE1 is decreased in breast cancer tissues compared to matched adjacent tissues, and its expression is positively correlated with patients' lifespan. These data indicate that TIPE1 suppresses breast cancer proliferation by inhibiting the ERK signaling pathway. This study also suggests that TIPE1 could serve as a potential therapeutic target and a diagnostic biomarker for breast cancer.

TIPE1作为一种细胞死亡调节因子，在癌症发生过程中已成为一种肿瘤抑制因子。然而，我们最近的研究表明，它在宫颈癌的发病机制中作为一种癌基因发挥作用，这提示TIPE1在癌症发生中的作用需要进一步评估。在本研究中，我们发现TIPE1能够在体内和体外抑制乳腺癌细胞的生长。在功能上，TIPE1主要通过下调ERK磷酸化来抑制癌细胞增殖。此外，与匹配的癌旁组织相比，TIPE1在乳腺癌组织中的表达降低，并且其表达与患者的生存期呈正相关。这些数据表明TIPE1通过抑制ERK信号通路来抑制乳腺癌增殖。本研究还提示TIPE1可作为乳腺癌的一个潜在治疗靶点和诊断生物标志物。