Highly Efficient, Catalyst-Free, Diastereoselective, Diversity-Oriented Synthesis of Dihydrocoumarin–Pyrrolidine–Spirooxindoles Bearing Three Contiguous Stereocenters

Abstract A new methodology has been developed for the highly efficient diastereoselective construction of dihydrocoumarin–pyrrolidine–spirooxindole collections via a domino Michael/annulation reaction of 3-isothiocyanato oxindoles and coumarins under cata

摘要：通过3 - 异硫氰酸基羟吲哚和香豆素在催化剂作用下的多米诺迈克尔/环化反应，开发了一种用于高效非对映选择性构建二氢香豆素 - 吡咯烷 - 螺羟吲哚化合物集合的新方法。