Association between vitamin D insufficiency and elevated serum uric acid among middle-aged and elderly Chinese Han women.

Association between vitamin D insufficiency and hyperuricemia has not been reported so far. We aimed to study the association of vitamin D insufficiency with elevated serum uric acid among middle-aged and elderly Chinese Han women. We collected data from participants residing in Jinchang district of Suzhou from January to May, 2010. Serum uric acid, 25-hydroxy vitamin D and other traditional biomarkers including fasting plasma glucose and blood lipids were determined in 1726 women aged above 30 years. Association between vitamin D insufficiency and elevated uric acid was analyzed in premenopausal and postmenopausal women, respectively. Among postmenopausal women, 25-hydroxy vitamin D level of participants with elevated uric acid was lower than that of those with normal uric acid (median [interquartile range]: 35[28–57] vs 40[32–58], µg/L; P = 0.006). Elevated uric acid was more prevalent in participants with vitamin D insufficiency compared to those without vitamin D insufficiency (16.50% vs 8.08%; P<0.001). Association between vitamin D insufficiency and elevated uric acid was not significant among premenopausal women. However, participants with vitamin D insufficiency were more likely to have elevated uric acid compared with those without vitamin D insufficiency among postmenopausal women (OR, 95% CI: 2.38, 1.47–3.87). Moreover, after excluding individuals with diabetes and/or hypertension, the association of vitamin D insufficiency with elevated uric acid was still significant (OR, 95% CI: 2.48, 1.17–5.44). Vitamin D insufficiency was significantly associated with elevated uric acid among postmenopausal Chinese Han women. This study suggested that a clinical trial should be conducted to confirm the association of vitamin D insufficiency with hyperuricemia.

到目前为止，维生素D缺乏与高尿酸血症之间的关联尚未见报道。我们旨在研究中国汉族中老年女性维生素D缺乏与血清尿酸升高之间的关联。 我们收集了2010年1月至5月居住在苏州金昌区参与者的数据。对1726名30岁以上女性测定了血清尿酸、25 - 羟基维生素D以及包括空腹血糖和血脂在内的其他传统生物标志物。分别对绝经前和绝经后女性维生素D缺乏与尿酸升高之间的关联进行了分析。 在绝经后女性中，尿酸升高的参与者的25 - 羟基维生素D水平低于尿酸正常者（中位数[四分位间距]：35[28 - 57]对40[32 - 58]，微克/升；P = 0.006）。与维生素D不缺乏者相比，维生素D缺乏的参与者中尿酸升高更为普遍（16.50%对8.08%；P < 0.001）。在绝经前女性中，维生素D缺乏与尿酸升高之间的关联不显著。然而，在绝经后女性中，与维生素D不缺乏者相比，维生素D缺乏者更有可能出现尿酸升高（比值比，95%置信区间：2.38，1.47 - 3.87）。此外，在排除糖尿病和/或高血压患者后，维生素D缺乏与尿酸升高之间的关联仍然显著（比值比，95%置信区间：2.48，1.17 - 5.44）。 在中国汉族绝经后女性中，维生素D缺乏与尿酸升高显著相关。这项研究提示应进行一项临床试验以确认维生素D缺乏与高尿酸血症之间的关联。