The current status of newborn screening.

Two decades of routine screening of newborns in the United States have yielded answers to many questions and raised others that remain to be answered. Addressed specifically in this overview are the value of follow-up tests for PKU, the T4-TSH strategy for detecting hypothyroidism, and questions posed by tests for disorders that may not be clinically significant or treatable.

美国20年来对新生儿的常规筛查已经回答了许多问题，同时也提出了其他一些仍有待回答的问题。本综述特别探讨了苯丙酮尿症（PKU）后续检测的价值、用于检测甲状腺功能减退症的T4 - 促甲状腺激素（TSH）策略，以及针对那些可能在临床上不显著或无法治疗的疾病检测所引发的问题。