Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal.

The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer tissues and cell lines into readily understandable genetic, epigenetic, gene expression, and proteomic events. The query interface combined with customized data storage enables researchers to interactively explore genetic alterations across samples, genes, and pathways and, when available in the underlying data, to link these to clinical outcomes. The portal provides graphical summaries of gene-level data from multiple platforms, network visualization and analysis, survival analysis, patient-centric queries, and software programmatic access. The intuitive Web interface of the portal makes complex cancer genomics profiles accessible to researchers and clinicians without requiring bioinformatics expertise, thus facilitating biological discoveries. Here, we provide a practical guide to the analysis and visualization features of the cBioPortal for Cancer Genomics.

癌症基因组学的cBioPortal（http://cbioportal.org）提供了一个网络资源，用于探索、可视化和分析多维癌症基因组学数据。该门户网站将来自癌症组织和细胞系的分子图谱数据简化为易于理解的遗传、表观遗传、基因表达和蛋白质组学事件。查询界面与定制的数据存储相结合，使研究人员能够交互式地探索样本、基因和通路之间的基因改变，并且当基础数据中存在相关信息时，能够将这些改变与临床结果联系起来。该门户网站提供来自多个平台的基因水平数据的图形摘要、网络可视化和分析、生存分析、以患者为中心的查询以及软件编程访问。该门户网站直观的网络界面使研究人员和临床医生无需生物信息学专业知识即可获取复杂的癌症基因组图谱，从而促进生物学发现。在此，我们为癌症基因组学的cBioPortal的分析和可视化功能提供一份实用指南。