CanVaxKB: a web-based cancer vaccine knowledgebase.

Cancer vaccines have been increasingly studied and developed to prevent or treat various types of cancers. To systematically survey and analyze different reported cancer vaccines, we developed CanVaxKB (https://violinet.org/canvaxkb), the first web-based cancer vaccine knowledgebase that compiles over 670 therapeutic or preventive cancer vaccines that have been experimentally verified to be effective at various stages. Vaccine construction and host response data are also included. These cancer vaccines are developed against various cancer types such as melanoma, hematological cancer, and prostate cancer. CanVaxKB has stored 263 genes or proteins that serve as cancer vaccine antigen genes, which we have collectively termed ‘canvaxgens’. Top three mostly used canvaxgens are PMEL, MLANA and CTAG1B, often targeting multiple cancer types. A total of 193 canvaxgens are also reported in cancer-related ONGene, Network of Cancer Genes and/or Sanger Cancer Gene Consensus databases. Enriched functional annotations and clusters of canvaxgens were identified and analyzed. User-friendly web interfaces are searchable for querying and comparing cancer vaccines. CanVaxKB cancer vaccines are also semantically represented by the community-based Vaccine Ontology to support data exchange. Overall, CanVaxKB is a timely and vital cancer vaccine source that facilitates efficient collection and analysis, further helping researchers and physicians to better understand cancer mechanisms.

癌症疫苗为预防或治疗多种类型的癌症而受到越来越多的研究和开发。为了系统地调查和分析不同报道的癌症疫苗，我们开发了CanVaxKB（https://violinet.org/canvaxkb），这是首个基于网络的癌症疫苗知识库，它汇集了670多种经过实验验证在不同阶段有效的治疗性或预防性癌症疫苗。还包括疫苗构建和宿主反应数据。这些癌症疫苗是针对多种癌症类型开发的，例如黑色素瘤、血液癌症和前列腺癌。CanVaxKB存储了263个作为癌症疫苗抗原基因的基因或蛋白质，我们将其统称为“canvaxgens”。最常用的前三个canvaxgens是PMEL、MLANA和CTAG1B，它们通常针对多种癌症类型。在与癌症相关的ONGene、癌症基因网络和/或桑格癌症基因共识数据库中也报道了总共193个canvaxgens。对canvaxgens的富集功能注释和聚类进行了识别和分析。用户友好的网络界面可供查询和比较癌症疫苗。CanVaxKB癌症疫苗还通过基于社区的疫苗本体进行语义表示，以支持数据交换。总体而言，CanVaxKB是一个及时且至关重要的癌症疫苗资源，有助于高效收集和分析，进一步帮助研究人员和医生更好地理解癌症机制。