Aberrant expression of hSef and Sprouty4 in endometrial adenocarcinoma.

Fibroblast growth factor (FGF) 2-mediated signaling of the mitogen-activated protein kinase/RAS/extracellular signal-regulated kinase 1/2 pathway is a critical modulator in angiogenesis and is therefore essential for the pathogenesis of endometrial carcinoma. Human similar expression to FGFs (hSef) and Sprouty4 have each been reported to be negative regulators of FGF signaling. The aim of the present study was to investigate the expression of hSef and Sprouty4 in human endometrial adenocarcinoma. Using immunohistochemistry analysis, the expression of hSef and Sprouty4 was detected in human endometrial adenocarcinomas. Increased hSef expression was found to be present in endometrial adenocarcinomas. In addition, decreased hSef expression was identified in the blood vessels of endometrial adenocarcinoma samples. However, the expression of Sprouty4 was downregulated in human endometrial adenocarcinoma. Aberrant expression of hSef and Sprouty4 are involved in the pathogenesis of human endometrial adenocarcinoma.

成纤维细胞生长因子（FGF）2介导的丝裂原活化蛋白激酶/RAS/细胞外信号调节激酶1/2通路的信号传导是血管生成的关键调节因子，因此对子宫内膜癌的发病机制至关重要。据报道，人类类成纤维细胞生长因子表达蛋白（hSef）和Sprouty4均为FGF信号传导的负调节因子。本研究的目的是探讨hSef和Sprouty4在人子宫内膜腺癌中的表达情况。通过免疫组织化学分析，检测了hSef和Sprouty4在人子宫内膜腺癌中的表达。发现子宫内膜腺癌中存在hSef表达增加。此外，在子宫内膜腺癌样本的血管中发现hSef表达降低。然而，Sprouty4在人子宫内膜腺癌中的表达下调。hSef和Sprouty4的异常表达参与了人子宫内膜腺癌的发病机制。