Effect of chromium chloride supplementation on glucose tolerance and serum lipids including high-density lipoprotein of adult men.

Chromium deficiency may cause insulin resistance, hyperinsulinemia, impaired glucose tolerance, and hyperlipidemia, recovered by chromium supplementation. The effect of chromium supplementation on serum lipids and glucose tolerance was tested in a double-blind 12-wk study of 23 healthy adult men aged 31 to 60 yr. Either 200 micrograms trivalent chromium in 5 ml water (Cr) or 5 ml plain water (W) was ingested daily 5 days each week. Half the subjects volunteered for glucose tolerance tests with insulin levels. At 12 wk high-density lipoprotein cholesterol increased in the Cr group from 35 to 39 mg/dl (p less than 0.05) but did not change in the water group (34 mg/dl). The largest increase in high-density lipoprotein cholesterol and decreases in insulin and glucose were found in those subjects having normal glucose levels together with elevated insulin levels at base-line. The data are thus consistent with the hypothesis that Cr supplementation raises high-density lipoprotein cholesterol and improves insulin sensitivity in those with evidence of insulin resistance but normal glucose tolerance.

铬缺乏可能导致胰岛素抵抗、高胰岛素血症、糖耐量受损和高脂血症，补充铬可使其恢复。在一项针对23名年龄在31至60岁的健康成年男性进行的为期12周的双盲研究中，测试了补充铬对血脂和糖耐量的影响。每周5天，每天摄入5毫升水中含200微克三价铬（Cr组）或5毫升纯水（W组）。一半的受试者自愿进行含胰岛素水平检测的糖耐量测试。12周时，Cr组的高密度脂蛋白胆固醇从35毫克/分升增加到39毫克/分升（p<0.05），而水组（34毫克/分升）没有变化。在基线时血糖水平正常但胰岛素水平升高的受试者中，高密度脂蛋白胆固醇的增加量最大，胰岛素和血糖的降低幅度也最大。因此，这些数据与以下假设相符：在有胰岛素抵抗迹象但糖耐量正常的人群中，补充铬可提高高密度脂蛋白胆固醇并改善胰岛素敏感性。