The oncogenic potential of a combination of hyperthermia and chemotherapy agents.

The modulating effect of 43 degrees C hyperthermia on the induction of oncogenic transformation by the antineoplastic agents, actinomycin D, mitomycin C, and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) was examined using the C3H 10T1/2 cell line. For any given level of cytotoxicity, cells exposed to the three chemotherapy agents at 37 degrees C showed similar frequencies of transformation. Transformation frequencies induced by all three drugs were reduced by hyperthermia. The reduction was most pronounced for cells exposed to BCNU, and to a lesser extent, by cells exposed to actinomycin D and mitomycin C. The modulating effects of heat on drug-induced transformation incidence appeared to be independent of whether application of heat and drug was concurrent or sequential.

使用C3H 10T1/2细胞系研究了43℃高温对放线菌素D、丝裂霉素C和1,3 - 双(2 - 氯乙基)-1 - 亚硝基脲(BCNU)等抗肿瘤药物诱导致癌转化的调节作用。对于任何给定的细胞毒性水平，在37℃下暴露于这三种化疗药物的细胞显示出相似的转化频率。高温降低了所有三种药物诱导的转化频率。这种降低在暴露于BCNU的细胞中最为显著，在暴露于放线菌素D和丝裂霉素C的细胞中程度较轻。热对药物诱导的转化发生率的调节作用似乎与热和药物是同时应用还是顺序应用无关。