Association Between Asymmetric Dimethylarginine and the Severity of Coronary Artery Disease in Patients with Chronic Kidney Disease

maTERial and mETHOdS: Eighty-eight (88) consecutive patients with decreased renal function (glomerular filtration rate (GFR) between 90 and 30 ml/min), undergoing cardiac catheterization for proven or clinically suspected coronary artery disease were enrolled at the study. Serum levels of creatinine, ADMA, nitric oxide (NO), calcium, phosphate, total cholesterol, HDL and LDL fractions, triglycerides were determined using measurement techniques. The Gensini scoring system was used for the detection of the severity of coronary atherosclerosis.

材料与方法：本研究纳入了88例连续的肾功能下降（肾小球滤过率在90 - 30 ml/min之间）的患者，这些患者因确诊或临床疑似冠状动脉疾病而接受心脏导管插入术。采用检测技术测定血清肌酐、不对称二甲基精氨酸（ADMA）、一氧化氮（NO）、钙、磷、总胆固醇、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）组分以及甘油三酯的水平。使用Gensini评分系统检测冠状动脉粥样硬化的严重程度。