The genes encoding the biotin carboxyl carrier protein and biotin carboxylase subunits of Bacillus subtilis acetyl coenzyme A carboxylase, the first enzyme of fatty acid synthesis

The genes encoding two subunits of acetyl coenzyme A carboxylase, biotin carboxyl carrier protein, and biotin carboxylase have been cloned from Bacillus subtilis. DNA sequencing and RNA blot hybridization studies indicated that the B. subtilis accB homolog which encodes biotin carboxyl carrier protein, is part of an operon that includes accC, the gene encoding the biotin carboxylase subunit of acetyl coenzyme A carboxylase.

编码乙酰辅酶A羧化酶的两个亚基、生物素羧基载体蛋白和生物素羧化酶的基因已从枯草芽孢杆菌中克隆出来。DNA测序和RNA印迹杂交研究表明，编码生物素羧基载体蛋白的枯草芽孢杆菌accB同源基因是一个操纵子的一部分，该操纵子包含accC，即编码乙酰辅酶A羧化酶的生物素羧化酶亚基的基因。