Positive Coombs Test in Hodgkin's Disease: Significance and Implications

To clarify the clinicopathologic characteristics of Coombs' positivity in Hodgkin's disease, the records of 71 cases were reviewed. The direct Coombs test was positive in seven. Mean age of the seven was 22 yr (range 11-33). All were males. All had extensive disease (pathologic stage III or IV) and six had systemic (B) symptoms. Four had mixed cellularity; three had nodular sclerosis. The positive Coombs test was detected at original diagnosis in three and at time of relapse in four. Although all were anemic, only three had evidence of overt hemolysis. The antibody responsible for Coombs positivity was characterized in three and fulfilled the criteria for IgG anti-ltThe presence of a positive direct Coombs test in the patient with Hodgkin's disease suggests active and advanced disease. The presence of IgG anti-ltmay represent a unique antibody in the Coombs-positive hemolytic anemia associated with Hodgkin's disease.

为阐明霍奇金病中库姆斯试验阳性的临床病理特征，对71例病例记录进行了回顾。7例直接库姆斯试验呈阳性。这7例患者的平均年龄为22岁（范围11 - 33岁），均为男性。所有患者病情均广泛（病理分期为III期或IV期），其中6例有全身（B）症状。4例为混合细胞型；3例为结节硬化型。3例在初诊时检测到库姆斯试验阳性，4例在复发时检测到阳性。尽管所有患者都有贫血，但只有3例有明显溶血的证据。在3例患者中对导致库姆斯试验阳性的抗体进行了鉴定，符合IgG抗 - （此处可能有遗漏信息）的标准。霍奇金病患者中直接库姆斯试验阳性提示疾病处于活动期且病情进展。IgG抗 - （此处可能有遗漏信息）的存在可能代表了与霍奇金病相关的库姆斯试验阳性溶血性贫血中的一种独特抗体。