Epidemiologic Features of Recovery From SARS-CoV-2 Infection

Key Points Question What variables are associated with time to recovery from SARS-CoV-2 infection? Findings In this cohort study of 4708 participants in a US meta-cohort, the median self-reported time to recovery from SARS-CoV-2 infection was 20 days, and an estimated 22.5% had not recovered by 90 days. Women and adults with suboptimal prepandemic health, particularly clinical cardiovascular disease, had longer times to recovery, whereas vaccination prior to infection and infection during the Omicron variant wave were associated with shorter times to recovery. Meaning These findings suggest that interventions to reduce severity of acute infection, such as vaccination, may help to mitigate the increased risk of persistent symptoms observed in women and adults with suboptimal prepandemic health.

要点问题 哪些变量与从新冠病毒感染中恢复的时间相关？ 研究结果 在这项针对美国一个综合队列中4708名参与者的队列研究中，自我报告的从新冠病毒感染中恢复的中位时间为20天，估计有22.5%的人在90天时仍未恢复。女性以及大流行前健康状况欠佳（尤其是有临床心血管疾病）的成年人恢复时间更长，而感染前接种疫苗以及在奥密克戎变异株流行期间感染则与更短的恢复时间相关。 意义 这些研究结果表明，诸如接种疫苗等减轻急性感染严重程度的干预措施，可能有助于降低在女性以及大流行前健康状况欠佳的成年人中观察到的持续症状风险增加的情况。