酒精性肾损害的研究进展

Excessive alcohol consumption can damage the structure and function of the kidney through both direct and indirect ways of action. Currently, it is believed that oxidative stress, inflammatory response caused by alcohol, and the complex interaction between them are involved in the direct damage of alcohol to the kidney. By analyzing two microarray data GSE81947 and GSE83529 in the GEO database, 59 differential genes affected by alcohol on the kidney were screened out. After retrieval, genes such as Gc, Cyp2d22, SLC22A3, Mgst1, Top2a, ArhGAP15, BDH1, Lpl, Ddx4, Agps are associated with the pathogenesis of the kidney and may be potential targets for the research on the mechanism of alcoholic kidney damage and drug screening.

过量饮酒可通过直接和间接两种作用方式损害肾的结构与功能,目前认为酒精所致的氧化应激、炎症反应以及两者之间的复杂交互作用参与了酒精对肾的直接损害。对GEO数据库中2个芯片数据GSE81947和GSE83529进行分析,筛选出59个酒精对肾影响的差异基因。经检索,其中Gc、Cyp2d22、SLC22A3、Mgst1、Top2a、ArhGAP15、BDH1、Lpl、 Ddx4、Agps等基因与肾的发病机制存在关联,可能是酒精性肾损害机制研究和药物筛选的潜在靶点。