Is there a CSF biomarker profile related to depression in elderly women?

In light of our previous observation of higher levels of cerebrospinal fluid (CSF) amyloid beta-42 (A beta 42) and CSF/serum albumin ratio in major depressive disorder (MDD), we analyzed two additional CSF biomarkers reflecting neurodegeneration-neurofilament protein light (NFL) and glial fibrillary acidic protein (GFAp)-in relationship to prevalent geriatric depression. Neuropsychiatric, physical, and lumbar puncture examinations, with DSM-III-R-based depression diagnoses and measurement of CSF levels of NFL and GFAp, were evaluated among a population-based sample of 78 elderly women (mean age, 73.9 +/- 3.2 years) without dementia for at least 10 years after CSF collection. Eleven (13.1%) women had MDD, and higher levels of NFL compared with women without depression. A multivariate model including age, NFL A beta 42 and the CSF/serum albumin ratio showed that each biomarker was independently and positively associated with MOD, and that this biomarker profile explained more variation in the model compared with single or combined biomarkers. A CSF profile with higher levels of NFL A beta 42, and CSF/serum albumin ratio may indicate neuropathological and vascular events in depression etiology. This contrasts with the well-characterized pattern of low A beta 42, higher CSF/serum albumin ratio, and higher NFL in Alzheimer's disease. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

鉴于我们先前观察到在重性抑郁症（MDD）中脑脊液（CSF）β - 淀粉样蛋白42（Aβ42）水平较高以及脑脊液/血清白蛋白比值较高，我们分析了另外两种反映神经退行性变的脑脊液生物标志物——神经丝轻链蛋白（NFL）和胶质纤维酸性蛋白（GFAp）与老年抑郁症患病率的关系。在一个基于人群的78名老年女性样本（平均年龄73.9 ± 3.2岁）中，在采集脑脊液后至少10年无痴呆的情况下，进行了神经精神、身体和腰椎穿刺检查，基于《精神疾病诊断与统计手册》第三版修订本（DSM - III - R）进行抑郁症诊断，并测量脑脊液中NFL和GFAp的水平。11名（13.1%）女性患有MDD，与无抑郁症的女性相比，NFL水平较高。一个包含年龄、NFL、Aβ42以及脑脊液/血清白蛋白比值的多元模型显示，每种生物标志物都与MDD独立且正相关，并且与单一或组合的生物标志物相比，这种生物标志物组合在模型中解释了更多的变异。脑脊液中NFL、Aβ42水平较高以及脑脊液/血清白蛋白比值较高的特征可能表明抑郁症病因中的神经病理和血管事件。这与阿尔茨海默病中特征明确的低Aβ42、较高脑脊液/血清白蛋白比值和较高NFL的模式形成对比。（C）2008爱思唯尔爱尔兰有限公司。保留所有权利。