Association between periodontitis and vascular endothelial function using noninvasive medical device-A pilot study.

The present study aimed to assess the relationship between periodontal condition and endothelial function using a noninvasive device. Many recent studies have reported associations between periodontitis and cardiovascular diseases. Endothelial dysfunction is the first step of atherosclerosis, but information on the association between periodontal disease and endothelial dysfunction remains limited. Thirty‐three subjects were recruited from among patients at a private medical clinic. We examined vascular endothelial function using a noninvasive medical device and periodontal measurements including probing pocket depth, attachment level, tooth mobility, and oral cleaning condition. Subjects were divided into two groups according to endothelial function score. Tooth mobility and number of lost teeth were increased in the group with endothelial dysfunction. A greater frequency of elderly subjects and altered hemoglobin A1c levels were seen in the endothelial dysfunction group. On multiple logistic regression analysis, increased tooth mobility was independently associated with endothelial dysfunction. Increased tooth mobility, a major periodontal parameter, appears related to endothelial dysfunction.

本研究旨在使用一种无创设备评估牙周状况与内皮功能之间的关系。许多近期研究报道了牙周炎与心血管疾病之间的关联。内皮功能障碍是动脉粥样硬化的第一步，但关于牙周疾病与内皮功能障碍之间关联的信息仍然有限。从一家私人医疗诊所的患者中招募了33名受试者。我们使用一种无创医疗设备检测了血管内皮功能，并进行了牙周测量，包括探诊牙周袋深度、附着水平、牙齿松动度和口腔清洁状况。根据内皮功能评分将受试者分为两组。在内皮功能障碍组中，牙齿松动度和缺失牙齿数量增加。在内皮功能障碍组中，老年受试者的比例更高，糖化血红蛋白A1c水平也有变化。在多元逻辑回归分析中，牙齿松动度增加与内皮功能障碍独立相关。作为一个主要的牙周参数，牙齿松动度增加似乎与内皮功能障碍有关。