The arduous road to achieving an immunosuppression-free state in kidney transplant recipients

Since the first successful transplantations were performed around 50 years ago, the lack of improvement in long-term graft survival and the risks associated with immunosuppressive therapy have made the ability to induce tolerance a burning desire among transplantation immunobiologists. These authors outline the considerable challenges that stand in the way of this goal, and proffer their opinion on which strategies are most likely to succeed.

自大约50年前首次成功进行移植手术以来，长期移植物存活率没有提高以及免疫抑制疗法相关的风险，使得诱导耐受性的能力成为移植免疫生物学家们的强烈渴望。这些作者概述了阻碍这一目标实现的诸多重大挑战，并就哪些策略最有可能成功提出了自己的观点。