人造碱基与人工合成生命

The article presents a panoramic review of the representative research achievements in the field of artificial bases and related artificially synthesized life. It focuses on introducing the two most important artificial base pairs, namely hydrogen bond complementarity and hydrophobicity, discusses the milestone six-nucleic acid molecule artificially synthesized life and its impact on the future development of synthetic biology, and briefly reviews the successful application examples of artificial bases in DNA detection and diagnosis kits, etc. Finally, it looks forward to the prospects and challenges of this research field.

文章就人造碱基及相关人工合成生命领域内的代表性研究成果进行了全景式综述，着重介绍了氢键互补及疏水性两种最为主要的人造碱基对，探讨了具有里程碑意义的六核酸分子人工合成生命及其对合成生物学未来发展的影响，简单综述了人造碱基在DNA检测诊断试剂盒等方面的成功应用实例。最后对这一研究领域的前景和面临的挑战进行了展望。