Risk of different precipitating events for progressing to acute-on-chronic liver failure in HBV-related cirrhotic patients

OBJECTIVEAcute-on-chronic liver failure (ACLF) is a distinct syndrome that develops in patients with cirrhosis and acute decompensation (AD). This study focused on the precipitating events (PEs) of hepatitis B virus (HBV)-related cirrhotic patients diagnosed as ACLF based on the Chronic Liver Failure Consortium organ failure (CLIF-C OF) score.METHODSHospitalized patients with HBV-related cirrhosis and AD were retrospectively included. The patients' characteristics, laboratory test results, PEs, CLIF-C OF score and short-term prognosis were evaluated.RESULTSOf the 890 patients enrolled 300 (33.7%) were diagnosed as ACLF and 590 (66.3%) without ACLF. ACLF patients had a higher incidence of PEs than those without ACLF. The ACLF patients were more prone to having PEs of bacterial infection (P

目的 慢加急性肝衰竭（ACLF）是一种在肝硬化和急性失代偿（AD）患者中发生的独特综合征。本研究基于慢加急性肝衰竭联盟器官衰竭（CLIF - C OF）评分，重点关注被诊断为ACLF的乙型肝炎病毒（HBV）相关肝硬化患者的诱发事件（PEs）。 方法 回顾性纳入HBV相关肝硬化和AD的住院患者。对患者的特征、实验室检测结果、诱发事件、CLIF - C OF评分以及短期预后进行评估。 结果 在纳入的890例患者中，300例（33.7%）被诊断为ACLF，590例（66.3%）未患ACLF。ACLF患者诱发事件的发生率高于未患ACLF的患者。ACLF患者更易发生细菌感染的诱发事件（P<......此处原文似乎不完整）