Assessing the SAfety and FEasibility of bedside portable low-field brain Magnetic Resonance Imaging in patients on ECMO (SAFE-MRI ECMO study): study protocol and first case series experience.

To assess the safety and feasibility of imaging of the brain with a point-of-care (POC) magnetic resonance imaging (MRI) system in patients on extracorporeal membrane oxygenation (ECMO). Early detection of acute brain injury (ABI) is critical in improving survival for patients with ECMO support. Patients from a single tertiary academic ECMO center who underwent head CT (HCT), followed by POC brain MRI examinations within 24 h following HCT while on ECMO. Primary outcomes were safety and feasibility, defined as completion of MRI examination without serious adverse events (SAEs). Secondary outcome was the quality of MR images in assessing ABIs. We report 3 consecutive adult patients (median age 47 years; 67% male) with veno-arterial (n = 1) and veno-venous ECMO (n = 2) (VA- and VV-ECMO) support. All patients were imaged successfully without SAEs. Times to complete POC brain MRI examinations were 34, 40, and 43 min. Two patients had ECMO suction events, resolved with fluid and repositioning. Two patients were found to have an unsuspected acute stroke, well visualized with MRI. Adult patients with VA- or VV-ECMO support can be safely imaged with low-field POC brain MRI in the intensive care unit, allowing for the assessment of presence and timing of ABI. The online version contains supplementary material available at 10.1186/s13054-022-03990-6.

评估在体外膜肺氧合（ECMO）患者中使用床旁（POC）磁共振成像（MRI）系统进行脑部成像的安全性和可行性。急性脑损伤（ABI）的早期检测对于提高ECMO支持患者的生存率至关重要。 来自一个三级学术ECMO中心的患者，在接受头部CT（HCT）检查后，在ECMO支持下于HCT检查后的24小时内接受了POC脑部MRI检查。主要结果是安全性和可行性，定义为在无严重不良事件（SAE）的情况下完成MRI检查。次要结果是评估ABI时MR图像的质量。 我们报告了3例连续的成年患者（中位年龄47岁；67%为男性），分别接受了静脉 - 动脉（n = 1）和静脉 - 静脉ECMO（n = 2）（VA - 和VV - ECMO）支持。所有患者均成功成像，无严重不良事件。完成POC脑部MRI检查的时间分别为34分钟、40分钟和43分钟。2例患者出现ECMO吸痰事件，通过补液和调整位置得以解决。2例患者被发现患有意外的急性脑卒中，MRI显示清晰。 在重症监护病房中，接受VA - 或VV - ECMO支持的成年患者可以使用低场强POC脑部MRI安全成像，从而能够评估ABI的存在和发生时间。 在线版本包含补充材料，可在10.1186/s13054 - 022 - 03990 - 6获取。