SNPStats:: a web tool for the analysis of association studies

A web-based application has been designed from a genetic epidemiology point of view to analyze association studies. Main capabilities include descriptive analysis, test for Hardy-Weinberg equilibrium and linkage disequilibrium. Analysis of association is based on linear or logistic regression according to the response variable (quantitative or binary disease status, respectively). Analysis of single SNPs: multiple inheritance models (co-dominant, dominant, recessive, over-dominant and log-additive), and analysis of interactions (gene-gene or gene-environment). Analysis of multiple SNPs: haplotype frequency estimation, analysis of association of haplotypes with the response, including analysis of interactions.

从遗传流行病学的角度设计了一个基于网络的应用程序来分析关联研究。主要功能包括描述性分析、哈迪 - 温伯格平衡检验和连锁不平衡检验。关联分析根据响应变量（分别为定量或二元疾病状态）基于线性或逻辑回归。单核苷酸多态性分析：多种遗传模型（共显性、显性、隐性、超显性和对数相加性），以及相互作用分析（基因 - 基因或基因 - 环境）。多个单核苷酸多态性分析：单倍型频率估计，单倍型与响应的关联分析，包括相互作用分析。