Factory-Calibrated Continuous Glucose Monitoring: How and Why It Works, and the Dangers of Reuse Beyond Approved Duration of Wear

Continuous glucose monitors (CGM) display real-time glucose values enabling greater glycemic awareness with reduced management burden. Factory-calibrated CGM systems allow for glycemic assessment without the pain and inconvenience of fingerstick glucose testing. Advances in sensor chemistry and CGM algorithms have enabled factory-calibrated systems to have greater accuracy than previous generations of CGM technology. Despite these advances many patients and providers are hesitant about the idea of removing fingerstick testing from their diabetes care. In this commentary, we aim to review the clinical trials on factory-calibrated CGM systems, present the algorithms which facilitate factory-calibrated CGMs to improve accuracy, discuss clinical use of factory-calibrated CGMs, and finally present two cases demonstrating the dangers of utilizing exploits in commercial systems to prolong sensor life.

持续葡萄糖监测仪（CGM）显示实时葡萄糖值，能在减轻管理负担的同时提高对血糖的了解。工厂校准的CGM系统无需进行指尖采血检测血糖，避免了疼痛和不便。传感器化学和CGM算法的进步使工厂校准系统比前几代CGM技术具有更高的准确性。尽管取得了这些进展，许多患者和医疗服务提供者对于在糖尿病护理中取消指尖采血检测这一想法仍犹豫不决。在这篇评论中，我们旨在回顾关于工厂校准CGM系统的临床试验，介绍有助于工厂校准CGM提高准确性的算法，讨论工厂校准CGM的临床应用，最后呈现两个案例，展示利用商业系统中的漏洞来延长传感器使用寿命的危害。