Liver cancer PET diagnosis tracer agent and preparation method and application thereof

The invention belongs to the field of radioactive drugs and nuclear medicine, and relates to a liver cancer PET diagnosis tracer agent and a preparation method and application thereof. A 18F marked anti-CD105 alpaca heavy-chain single-domain antibody is shown as a structural formula: 18F-anti-CD105 alpaca heavy-chain single-domain antibody. Animal experiments show that the 18F marked anti-CD105 alpaca heavy-chain single-domain antibody has the advantages that on one hand, uptake values of tumors for the antibody and tumor imaging sensitivity are both high; on the other hand, uptake values of the liver for the antibody is quite low, and accordingly the antibody causes little toxic or side effect on the liver. Thus, the 18F marked anti-CD105 alpaca heavy-chain single-domain antibody can be used as the PET diagnosis tracer agent and the liver cancer PET diagnosis tracer agent in particular.

本发明属于放射性药物和核医学领域，涉及一种肝癌PET诊断示踪剂及其制备方法和应用。一种¹⁸F标记的抗CD105羊驼重链单域抗体，其结构式为：¹⁸F - 抗CD105羊驼重链单域抗体。动物实验表明，¹⁸F标记的抗CD105羊驼重链单域抗体一方面肿瘤对该抗体的摄取值以及肿瘤成像灵敏度均较高；另一方面肝脏对该抗体的摄取值相当低，因此该抗体对肝脏的毒副作用小。因此，¹⁸F标记的抗CD105羊驼重链单域抗体可作为PET诊断示踪剂，特别是作为肝癌PET诊断示踪剂。