Recent advances in nanoscale metal-organic frameworks biosensors for detection of biomarkers

Early and precise diagnosis are propitious to timely treatment and simultaneously increase the chance of successful treatments. It is of critical importance to develop rapid, sensitive, and reliable sensing techniques of physiological biomarkers for disease diagnosis. Due to the advantages of structural designability and property tunability, nanoscale metal-organic frameworks (nMOFs) have been widely applied in the field of biomedicine in recent years. Particularly, enhanced stability, more modification sites and improved distribution make nMOFs more suitable as biosensors for detection of biomarkers. This review article will summarize the recent advancements of nMOFs-based biosensors for detection of biomarkers, classified into four sections via different sensing modes: fluorescent sensing, colorimetric sensing, electrochemical sensing and surface-enhanced Raman scattering (SERS) sensing within the latest years. Except introducing and comparing the role of nMOFs in different sensing modes, designing strategies of nMOFs-based biosensors are involved as well. At last, a brief conclusion and outlook for further applications are provided, which is helpful for exploring multi-functional biologic nano-platforms with nMOFs. We expect that this review can inspire the interest on this promising research area of nMOFs-based biosensors for detection of biomarker and early diagnosis.

早期且精确的诊断有利于及时治疗，同时增加治疗成功的几率。开发用于疾病诊断的快速、灵敏且可靠的生理生物标志物传感技术至关重要。由于具有结构可设计性和性能可调节性的优势，纳米级金属 - 有机框架（nMOFs）近年来在生物医学领域得到了广泛应用。特别是，增强的稳定性、更多的修饰位点以及更好的分布使nMOFs更适合作为检测生物标志物的生物传感器。这篇综述文章将总结近年来基于nMOFs的生物传感器在生物标志物检测方面的最新进展，按照不同的传感模式分为四个部分：荧光传感、比色传感、电化学传感以及表面增强拉曼散射（SERS）传感。除了介绍和比较nMOFs在不同传感模式中的作用外，还涉及基于nMOFs的生物传感器的设计策略。最后，提供了一个简要的结论以及对进一步应用的展望，这有助于探索具有nMOFs的多功能生物纳米平台。我们期望这篇综述能够激发人们对基于nMOFs的生物传感器用于生物标志物检测和早期诊断这一有前景的研究领域的兴趣。