Dynamic regulation of the structure and functions of integrin adhesions.

Integrin-mediated cell adhesions to the extracellular matrix (ECM) contribute to tissue morphogenesis and coherence and provide cells with vital environmental cues. These apparently static structures display remarkable plasticity and dynamic properties: they exist in multiple, interconvertible forms that are constantly remodeled in response to changes in ECM properties, cytoskeletal organization, cell migration, and signaling processes. Thus, integrin-mediated environmental sensing enables cells to adapt to chemical and physical properties of the surrounding matrix by modulating their proliferation, differentiation, and survival. This intriguing interplay between the apparently robust structure of matrix adhesions and their highly dynamic properties is the focus of this article.

整合素介导的细胞与细胞外基质（ECM）的黏附有助于组织形态发生和连贯性，并为细胞提供重要的环境信号。这些看似静态的结构表现出显著的可塑性和动态特性：它们以多种可相互转换的形式存在，会根据细胞外基质特性、细胞骨架组织、细胞迁移以及信号传导过程的变化而不断重塑。因此，整合素介导的环境感知使细胞能够通过调节其增殖、分化和存活来适应周围基质的化学和物理特性。基质黏附看似稳固的结构与其高度动态特性之间这种有趣的相互作用是本文的重点。