Microfluidic encapsulated manganese organic frameworks as enzyme mimetics for inflammatory bowel disease treatment

Metal organic frameworks (MOFs) with physicochemical properties and adjustable structures have been proposed as very attractive materials. The studies on development of such functional materials tended to fabricate featured MOF objects with fascinating catalytic capabilities to utilize their biomedical values. In this paper, we present novel biocompatible manganese metal organic framework (Mn-MOF)-based catalase mimetics with microfluidic microcapsule encapsulation for intravital inflammatory bowel disease (IBD) treatment. Phosphoserine, a component of the cell membrane, served as an organic ligand to ensure biocompatibility of Mn-MOF. Owing to the core-shell structure of the microcapsule, the Mn-MOF exhibited a well-organized distribution and controlled release features, which could protect them from gastric juice and provide function in the intestine. Upon reaching the sites of the inflammatory bowel, Mn-MOF could effectively scavenge reactive oxygen species (ROS) over-produced by neutrophils and macrophages under various gastrointestinal pH environments, protecting intestinal epithelial cells from ROS damage. The Mn-MOF-encapsulated microcapsules exhibited high performances in treating spontaneous IBD in interleukin-10-deficient mice by relieving the oxidative stress, reducing the inflammation, and restoring the intestinal barrier. These results indicate that the functional Mn-MOF-encapsulated microcapsules have practical applications in the treatment of ROS-associated diseases. (c) 2021 Elsevier Inc. All rights reserved.

具有物理化学性质和可调节结构的金属有机框架（MOFs）被认为是极具吸引力的材料。对这类功能材料开发的研究倾向于制造具有迷人催化能力的特色MOF物体，以利用其生物医学价值。在本文中，我们介绍了一种新型的基于生物相容性锰金属有机框架（Mn - MOF）的过氧化氢酶模拟物，其采用微流控微胶囊封装，用于治疗活体炎症性肠病（IBD）。磷酸丝氨酸作为细胞膜的一种成分，用作有机配体以确保Mn - MOF的生物相容性。由于微胶囊的核 - 壳结构，Mn - MOF呈现出有序的分布和控释特性，这可以保护它们免受胃液影响，并在肠道中发挥作用。当到达炎症性肠道部位时，Mn - MOF能够在各种胃肠道pH环境下有效清除中性粒细胞和巨噬细胞过度产生的活性氧物质（ROS），保护肠上皮细胞免受ROS损伤。封装有Mn - MOF的微胶囊通过缓解氧化应激、减轻炎症和恢复肠道屏障，在治疗白细胞介素 - 10缺陷小鼠的自发性IBD方面表现出良好性能。这些结果表明，功能性的封装有Mn - MOF的微胶囊在治疗与ROS相关的疾病方面具有实际应用价值。（c）2021爱思唯尔公司。保留所有权利。