Management of infantile subglottic hemangioma: Acebutolol or propranolol?

The successful management of subglottic hemangioma with propranolol has been reported. We report three cases of subglottic hemangioma treated with the cardioselective beta-blocker acebutolol, 8 mg/kg/day. Treatment was efficient in two cases while an open procedure was necessary in the third child. In our experience, acebutolol could be easily administered in oral form twice-a-day only with a dose that was adaptable according to the growth of the child and showed no side effects.We also report a case of rebound growth after beta-mimetic drug use and the efficiency of propranolol treatment in such a recurrence.Considering the lack of side effects and the advantages in terms of administration, we suggest acebutolol as a first-line treatment of subglottic hemangiomas for which intervention is required. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

已有报道使用普萘洛尔成功治疗声门下血管瘤。我们报告3例声门下血管瘤病例，采用心脏选择性β受体阻滞剂醋丁洛尔治疗，剂量为8mg/kg/天。2例治疗有效，第3例患儿则需行开放性手术。以我们的经验，醋丁洛尔可方便地以口服形式每日给药2次，且剂量可根据患儿生长情况调整，无副作用。我们还报告1例使用β受体激动剂后出现反弹生长的病例，以及普萘洛尔治疗此类复发的有效性。考虑到无副作用以及给药方面的优势，我们建议将醋丁洛尔作为需干预治疗的声门下血管瘤的一线治疗药物。（C）2010爱思唯尔爱尔兰有限公司。保留所有权利。