Microbiological characterization of a population affected by periodontitis with different levels of bone health

ntroduction: Both osteoporosis and periodontitis are diseases characterized by deficits at the level of bone tissue, where bone resorption exceeds neo-formation, resulting in bone loss. Materials and methods: In the context of a monocentric cross-sectional observational study carried out through the collaboration between the University of Florence and the private dentistry institute Excellence Dental Network, 110 subjects affected by periodontitis were recruited. Of these, 71 were also affected by osteoporosis or osteopenia and 39 were not osteoporotic or osteopenic. Data were collected on oral microbiota, oral health and bone health. Results: The collected data reveal a population of frail subjects in terms of fracture risk. The most common forms of periodontitis were essentially chronic in nature, and mainly of a moderate or even severe type, with high gingival recession and periodontal pocket depth values. The microbial species associated with Socransky's red and orange complexes showed concentration values nearly always above 10³ copies/mL. Conclusions: The relationship between osteoporosis and periodontitis still needs to be explored in depth. Data from our analyses are certainly interesting and provide a basis for designing further studies in larger populations. KEY WORDS: Periodontal disease, bone disease, oral microbiota.

引言：骨质疏松症和牙周炎均是以骨组织层面的缺陷为特征的疾病，其中骨吸收超过新骨形成，导致骨质流失。 材料与方法：在佛罗伦萨大学与私立牙科机构卓越牙科网络合作开展的一项单中心横断面观察性研究中，招募了110名患有牙周炎的受试者。其中，71人还患有骨质疏松症或骨质减少症，39人没有骨质疏松或骨质减少。收集了口腔微生物群、口腔健康和骨骼健康方面的数据。 结果：所收集的数据显示，就骨折风险而言，这是一群身体虚弱的受试者。牙周炎最常见的形式本质上基本为慢性，主要为中度甚至重度类型，牙龈退缩和牙周袋深度值较高。与索兰斯基红色和橙色复合体相关的微生物种类的浓度值几乎总是高于10³拷贝/毫升。 结论：骨质疏松症和牙周炎之间的关系仍需深入探究。我们的分析数据当然很有趣，并为在更大人群中设计进一步的研究提供了基础。 关键词：牙周疾病，骨疾病，口腔微生物群