基于糖烯的碳苷合成方法研究进展

C-glycosides are a class of carbohydrate natural products with various biological activities, and the construction of their unique C - C glycosidic bonds is a hot and difficult topic in carbohydrate chemistry research. The construction of new C - C bonds through double bond functional groups is a commonly used strategy in organic chemistry. With the rapid development of ene chemistry, sugar ene donors containing 1,2 - double bonds have also made remarkable progress in the synthesis of C - glycosides. The methods for the synthesis of C - glycosides based on sugar enes in recent years are summarized from aspects such as Ferrier type I C - glycosylation reactions, Heck coupling type C - glycosylation reactions, transition metal - catalyzed coupling C - glycosylation reactions of 1 - substituted sugar enes, Michael addition type and radical addition type C - glycosylation reactions of 2 - substituted sugar enes.

碳苷是一类具有多种生物活性的糖类天然产物,其独特的C-C糖苷键构筑是糖化学研究中的热点和难点.通过双键官能团构建新的C-C键是有机化学中的常用策略.随着烯化学的飞速发展,含1,2-位双键的糖烯供体在碳苷合成中也取得了显著进步.从Ferrier I型碳苷化反应、Heck偶联型碳苷化反应、1-取代糖烯的过渡金属催化偶联碳苷化反应、2-取代糖烯的Michael加成型和自由基加成型碳苷化反应等方面,总结近年来基于糖烯的碳苷合成方法.