Progress on the Biological Activities of Helicid and its Derivatives

Helicid is a specific Chinese natural drug. Helicid, its congeners, and its derivatives.exhibit pronounced biological activities, among which its hypnotic effects stand out..The well-documented sedation and analgesic activity and low side effects of helicid have.drawn more and more attention from scientists. Moreover, its clinical success and intriguing.mechanism of action have stimulated great interest in further modification of helicid.for improving its hypnotic activity. The 4-formyl group has been a major target for structural.derivatization aimed at either producing more potent compounds or overcoming drug.disadvantages. Accordingly, numerous helicid derivatives have been prepared via molecular.docking and hemisynthesis. Although neither systematic nor comprehensive, there are.two excellent reviews on the distribution, sources, applications, synthesis, and pharmacological.activity of helicid that have been published in Chinese. In the present review, we attempt to compile and.discuss the key data available in the literature on the multiple biological activities of helicid derivatives. This.compilation of 102 references may be helpful in understanding the diverse biological properties of helicid.while providing insights into its mechanism of action. This may direct future research in the synthesis of new.derivatives and the exploration of other biological activities.

豆腐果苷是一种中国特有的天然药物。豆腐果苷及其同系物和衍生物具有显著的生物活性，其中其催眠作用尤为突出。豆腐果苷有充分记载的镇静和镇痛活性以及低副作用越来越受到科学家的关注。此外，它在临床上的成功以及有趣的作用机制激发了人们对进一步修饰豆腐果苷以提高其催眠活性的极大兴趣。4 - 醛基一直是结构衍生化的主要目标，旨在产生更有效的化合物或克服药物的缺点。因此，通过分子对接和半合成制备了许多豆腐果苷衍生物。虽然既不系统也不全面，但在中国已经发表了两篇关于豆腐果苷的分布、来源、应用、合成和药理活性的优秀综述。在本综述中，我们试图汇编和讨论文献中关于豆腐果苷衍生物多种生物活性的关键数据。这102篇参考文献的汇编可能有助于理解豆腐果苷的多种生物学特性，同时提供对其作用机制的深入了解。这可能会指导未来在新衍生物合成和其他生物活性探索方面的研究。