Basic Science Reviews

Patients with head and neck cancer have immune impairment, demonstrable at several levels, often related to the clinical tumor stage. Researchers have focused on this unique system to understand locoregional cancer biology and to develop new therapeutic strategies. Along with classic cellular immunology, which has already resulted in several new theories and therapies, recent molecular biologic data are providing stimulating insights into cancer immunology and the larger field of tumor-host interactions.

头颈部癌症患者存在免疫功能受损，在多个层面都有所体现，且往往与临床肿瘤分期相关。研究人员一直关注这一独特的系统，以了解局部区域癌症生物学，并制定新的治疗策略。除了已经催生出若干新理论和疗法的经典细胞免疫学之外，近期的分子生物学数据也为癌症免疫学以及更广泛的肿瘤 - 宿主相互作用领域提供了令人振奋的见解。