Co-expression analysis and ceRNA network reveal eight novel potential lncRNA biomarkers in hepatocellular carcinoma

Background. Hepatocellular carcinoma (HCC) is the most common primary liver cancer in the world, with a high degree of malignancy and recurrence. The influence of the ceRNA network in tumor on the biological function of liver cancer is very important, It has been reported that many lncRNA play a key role in liver cancer development. In our study, integrated data analysis revealed potential eight novel lncRNA biomarkers in hepatocellular carcinoma.Methods. Transcriptome data and clinical data were downloaded from the The Cancer Genome Atlas (TCGA) data portal. Weighted gene co-expression network analysis was performed to identify the expression pattern of genes in liver cancer. Then, the ceRNA network was constructed using transcriptome data.Results. The integrated analysis of miRNA and RNAseq in the database show eight novel lncRNAs that may be involved in important biological pathways, including TNM and disease development in liver cancer. We performed function enrichment analysis of mRNAs affected by these lncRNAs.Conclusions. By identifying the ceRNA network and the lncRNAs that affect liver cancer, we showed that eight novel lncRNAs play an important role in the development and progress of liver cancer.

背景。肝细胞癌（HCC）是世界上最常见的原发性肝癌，具有高度的恶性和复发性。肿瘤中的竞争性内源RNA（ceRNA）网络对肝癌生物学功能的影响非常重要。据报道，许多长链非编码RNA（lncRNA）在肝癌发展中起关键作用。在我们的研究中，综合数据分析揭示了肝细胞癌中潜在的8种新型lncRNA生物标志物。 方法。从癌症基因组图谱（TCGA）数据门户下载转录组数据和临床数据。进行加权基因共表达网络分析以确定肝癌中基因的表达模式。然后，利用转录组数据构建ceRNA网络。 结果。对数据库中微小RNA（miRNA）和RNA测序的综合分析显示出8种新型lncRNAs可能参与重要的生物学通路，包括肝癌的TNM分期和疾病发展。我们对受这些lncRNAs影响的信使RNA（mRNAs）进行了功能富集分析。 结论。通过确定ceRNA网络和影响肝癌的lncRNAs，我们表明8种新型lncRNAs在肝癌的发生和发展中起重要作用。