Cardiac positron emission tomography. A report for health professionals from the Committee on Advanced Cardiac Imaging and Technology of the Council on Clinical Cardiology, American Heart Association.

T hisstatement oftheCommittee on Advanced Cardiac Imaging andTechnology ofthe Council on Clinical Cardiology addresses the use ofpositron emission tomography (PET)as a clinical toolforthediagnosis andmanagementof patients withcoronaryartery disease. Overthepast decade PETtechnology hasevolved tothepoint that clinical PET studies can beperformed safely and efficiently intheevaluation ofpatients withknownor suspected coronaryartery disease. Twospecific uses ofPET inmanagementofcoronaryartery disease havebeenproposed: 1)noninvasive detection of coronaryartery disease andestimation ofitsseverity and2)assessment ofmyocardial viability inpatients withcoronaryarterydisease andleftventricular dysfunction. Thediagnostic useofPETwouldapply toa large numberofpatients, whereas itsuse to assessmyocardial viability wouldapply toa smaller, more select numberofpatients. AsofFebruary 1991, theavailable datathathave emerged fromthefewcenters withsufficient experienceincardiac PETindicate thatthis promising and advanced imaging modality canoften provide accurate information inbothoftheseclinical situations. PET allows more sensitive dataacquisition thansingle photon emission computed tomography (SPECT). In addition, coincidence detection provides a means of measuring tissue photon attenuation forsubsequent correction ofemission data. Inclinical practice, such attenuation correction results inimproved delineation ofregional tracer concentration compared withcurrentSPECTmethods. Present-generation

美国心脏病学会临床心脏病学分会先进心脏成像与技术委员会的这份声明阐述了正电子发射断层扫描（PET）作为一种临床工具在冠心病患者诊断和治疗中的应用。在过去的十年中，PET技术已经发展到可以在已知或疑似冠心病患者的评估中安全、高效地进行临床PET研究的程度。PET在冠心病治疗中的两种具体应用已被提出：1）冠心病的无创检测以及对其严重程度的评估；2）对冠心病合并左心室功能障碍患者心肌活力的评估。PET的诊断用途适用于大量患者，而其用于评估心肌活力则适用于较少的、经过更严格挑选的患者。截至1991年2月，从少数具有丰富心脏PET经验的中心所获得的数据表明，这种有前途的先进成像方式在这两种临床情况下常常能够提供准确的信息。PET比单光子发射计算机断层扫描（SPECT）能够获取更敏感的数据。此外，符合探测为测量组织光子衰减提供了一种方法，以便随后对发射数据进行校正。在临床实践中，与目前的SPECT方法相比，这种衰减校正可使局部示踪剂浓度的描绘更加清晰。当代的……