Relationship between blood pressure and airway obstruction during sleep in the dog.

The relationship between airway obstruction during sleep and changes in mean arterial pressure (MAP) was investigated in four chronically instrumented tracheostomized dogs during 12-h nocturnal experiments. The MAP response was determined 1) during experimental airway obstruction whenever sleep occurred, 2) over each 12-h experiment, and 3) during a 2-h recovery period at the end of each experiment. The effects of 24 h of sleep deprivation and changes in plasma levels of renin and atrial natriuretic peptide were assessed. In non-rapid-eye-movement sleep, a period of airway obstruction caused MAP to increase (P < 0.002) from 95 +/- 3 (SE) mmHg to 112 +/- 3 mmHg, and this difference was enhanced (P < 0.04) by sleep deprivation. There was an increase of 12 +/- 2 mmHg in the overall MAP over time (P < 0.001) in non-rapid-eye-movement sleep that was sustained in the 2-h recovery period. Plasma levels of renin and atrial natriuretic peptide were constant and unrelated to changes in MAP. We conclude that in the sleeping dog airway obstruction causes an increase in MAP that can be accentuated by prior sleep deprivation and that repetitive airway obstruction will cause an increase in MAP over time that is sustained for > or = 2 h when normal airway patency is restored.

在12小时夜间实验中，对4只长期安装仪器且做了气管造口术的狗研究了睡眠期间气道阻塞与平均动脉压（MAP）变化之间的关系。MAP反应通过以下方式确定：1）在实验性气道阻塞期间且无论何时发生睡眠时；2）在每次12小时实验过程中；3）在每次实验结束时的2小时恢复期。评估了24小时睡眠剥夺的影响以及肾素和心房利钠肽血浆水平的变化。在非快速眼动睡眠中，一段气道阻塞期使MAP从95±3（标准误）mmHg增加（P < 0.002）到112±3 mmHg，并且这种差异因睡眠剥夺而增强（P < 0.04）。在非快速眼动睡眠中，随着时间推移，总体MAP增加了12±2 mmHg（P < 0.001），并且在2小时恢复期内这种增加得以维持。肾素和心房利钠肽的血浆水平保持恒定，与MAP的变化无关。我们得出结论，在睡眠中的狗，气道阻塞导致MAP升高，这种升高可因先前的睡眠剥夺而加剧，并且反复的气道阻塞会随着时间推移导致MAP升高，当气道恢复正常通畅时，这种升高会持续≥2小时。