Long non-coding RNA MAGI2-AS3 inhibits breast cancer cell migration and invasion via sponging microRNA-374a

Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts that play important roles in tumorigenesis and tumor progression. Our study aimed to explore the role of lncRNA MAGI2-AS3 in breast cancer metastatic progression. In the present study, our results showed that MAGI2-AS3 can inhibit the migration and invasion of breast cancer cells. In addition, an increase in MAGI2-AS3 can inhibit microRNA-374a (miR-374a) expression in breast cancer cells. Bioinformatic analysis predicted the correlation between MAGI2-AS3 and miR-374a. Phosphatase and tensin homolog (PTEN) was found to be an novel mRNA target of miR-374a. MAGI2-AS3 upregulation inhibited breast cancer metastatic progression by decreasing miR-374a and enhancing PTEN expression. Together, our data revealed that lncRNA MAGI2-AS3 is involved in breast cancer cell progression by regulating the miR-374a-PTEN axis. These findings offer new insight into treatment strategies for breast cancer.

长链非编码RNA（lncRNAs）是不编码蛋白质的转录本，在肿瘤发生和肿瘤进展中发挥重要作用。我们的研究旨在探索lncRNA MAGI2 - AS3在乳腺癌转移进展中的作用。在本研究中，我们的结果表明，MAGI2 - AS3能够抑制乳腺癌细胞的迁移和侵袭。此外，MAGI2 - AS3的增加能够抑制乳腺癌细胞中微小RNA - 374a（miR - 374a）的表达。生物信息学分析预测了MAGI2 - AS3和miR - 374a之间的相关性。磷酸酶和张力蛋白同源物（PTEN）被发现是miR - 374a的一个新的mRNA靶点。MAGI2 - AS3的上调通过降低miR - 374a并增强PTEN的表达来抑制乳腺癌转移进展。总之，我们的数据显示lncRNA MAGI2 - AS3通过调节miR - 374a - PTEN轴参与乳腺癌细胞进展。这些发现为乳腺癌的治疗策略提供了新的见解。