NF-κB and STAT3 in glioblastoma: therapeutic targets coming of age.

Since we last addressed the roles of NF-κB and JAK/STAT3 signaling in glioblastoma (GBM) five years ago, tremendous strides have been made in the understanding of these two pathways in glioma biology. Contributing to prosurvival mechanisms, cancer stem cell maintenance, and treatment resistance, both NF-κB and STAT3 have been characterized as major drivers of GBM. In this review, we address general improvements in the molecular understanding of GBM, the structure of NF-κB and STAT3 signaling, the ways in which these pathways contribute to GBM, and advances in preclinical and clinical targeting of these two signaling cascades.

自从我们五年前上次阐述核因子 - κB（NF - κB）和JAK/STAT3信号通路在胶质母细胞瘤（GBM）中的作用以来，在理解这两条通路在胶质瘤生物学中的作用方面已经取得了巨大进展。NF - κB和STAT3都有助于促生存机制、癌症干细胞维持以及治疗抵抗，已被认定为胶质母细胞瘤的主要驱动因素。在这篇综述中，我们阐述了在对胶质母细胞瘤的分子理解方面的总体进展、NF - κB和STAT3信号通路的结构、这些通路对胶质母细胞瘤的作用方式，以及针对这两条信号级联在临床前和临床方面的研究进展。