Diurnal Variation of Serum Insulin-like Growth Factor Binding Protein-1 in Three Boys and Fasting Insulin-like Growth Factor Binding Protein-1 Levels in Normal Children

It is reported that insulin-like growth factor binding protein-1 (IGFBP-1) is one of the IGFBPs and modulates the IGF action (1). Since IGFBP-1 is reported to be regulated by insulin, it is speculated that meals and nutritional condition influence IGFBP-1 secretion from the liver (2). We measured the 24 hour secretion of serum IGFBP-1 to study the diurnal variation and the relation with calorie intake. We also measured IGFBP-1 levels in fasting normal children to study the age dependent reference value.

据报道，胰岛素样生长因子结合蛋白 -1（IGFBP -1）是胰岛素样生长因子结合蛋白之一，可调节胰岛素样生长因子的作用（1）。由于据报道IGFBP -1受胰岛素调节，因此推测进餐和营养状况会影响肝脏分泌IGFBP -1（2）。我们测量了血清IGFBP -1的24小时分泌情况，以研究其昼夜变化以及与热量摄入的关系。我们还测量了正常儿童空腹时的IGFBP -1水平，以研究其年龄相关的参考值。