Anticholinergic effects and plasma desipramine levels

Anticholinergic effects of the tricyclic antidepressant desipramine were studied in 12 outpatients. Objective measurements of salivation and pulse rate and subjective ratings of mouth dryness and palpitations were made before and during treatment with desipramine at a final daily dosage of 150 mg. There were significant changes after 3 wk of treatment in all parameters except ratings of palpitation. Subjects with moderate or high plasma desipramine levels had more suppression of salivation than those with low levels. Changes in salivation and pulse did not correlate, nor did they correlate with subjective reports.

对12名门诊患者研究了三环类抗抑郁药地昔帕明的抗胆碱能作用。在使用最终日剂量为150毫克的地昔帕明治疗前和治疗期间，对唾液分泌和脉搏率进行了客观测量，并对口干和心悸进行了主观评分。治疗3周后，除心悸评分外，所有参数均有显著变化。血浆地昔帕明水平中等或较高的受试者比水平较低的受试者唾液分泌抑制更明显。唾液分泌和脉搏的变化没有相关性，它们与主观报告也没有相关性。