Solid Tumor Second Primary Neoplasms: Who Is at Risk, What Can We Do?

Eighteen percent of incident malignancies in the United States are a second (or subsequent) cancer. Second primary neoplasms (SPNs), particularly solid tumors, are a major cause of mortality and serious morbidity among cancer survivors successfully cured of their first cancer. Multiple etiologies may lead to a cancer survivor subsequently being diagnosed with an SPN, including radiotherapy for the first cancer, unhealthy lifestyle behaviors, genetic factors, aging, or an interaction between any of these factors. In this article, we discuss these factors and synthesize this information for use in clinical practice, including preventive strategies and screening recommendations for SPNs. (C) 2013 Elsevier Inc. All rights reserved.

在美国，18%的恶性肿瘤为二次（或多次）癌症。第二原发肿瘤（SPNs），尤其是实体瘤，是成功治愈首次癌症的癌症幸存者死亡和严重发病的主要原因。多种病因可能导致癌症幸存者随后被诊断出患有SPN，包括首次癌症的放疗、不健康的生活方式行为、遗传因素、衰老，或者这些因素之间的相互作用。在本文中，我们讨论了这些因素，并综合这些信息以便用于临床实践，包括针对SPNs的预防策略和筛查建议。（C）2013爱思唯尔公司。保留所有权利。