A two dimensional simulation of microtubule dynamics

We propose a two dimensional model to simulate microtubule dynamics. Microtubules are polymers that are important in many cell functions including cell division. In particular, chemotherapy targets microtubule dynamics in order to slow cancer cell reproduction. Traditional stochastic or chemical models for microtubule dynamics are one-dimensional, focusing on one variable such as length or concentration. We combine a traditional microtubule instability model and a chemical model and propose a two dimensional space for these models to interact. This gives a more realistic simulation of microtubule dynamics as it allows interaction of different microtubules. It can also simulate microtubule movement under different conditions. Our approach quantifies microtubule images and models microtubule dynamics within a synthesis-analysis framework.

我们提出一个二维模型来模拟微管动力学。微管是在许多细胞功能（包括细胞分裂）中都很重要的聚合物。特别是，化疗以微管动力学为靶点，以减缓癌细胞的繁殖。传统的微管动力学随机模型或化学模型是一维的，侧重于一个变量，如长度或浓度。我们将一个传统的微管不稳定性模型和一个化学模型相结合，并为这些模型的相互作用提出一个二维空间。这使得对微管动力学的模拟更加真实，因为它允许不同微管之间的相互作用。它还可以模拟不同条件下微管的运动。我们的方法对微管图像进行量化，并在一个综合分析框架内对微管动力学进行建模。