The Liebeskind-Srogl Cross-Coupling Reaction and its Synthetic Applications

The Pd-catalyzed, Cu-I-carboxylate-mediated cross-coupling reaction of organosulfur compounds with nucleophilic organometallic reagents is known as the Liebeskind-Srogl cross-coupling reaction. Owing to the readily available starting materials and neutral reaction conditions, it has become an attractive procedure for the formation of carbon-carbon bonds, in particular for cases in which traditional methods had failed. Since the seminal work of Liebeskind and Srogl in 2000, this reaction has received intense attention from the synthetic community. In this Focus Review, we highlight recent advances in this intriguing cross-coupling reaction and its applications in organic synthesis.

钯催化、碘化亚铜 - 羧酸盐介导的有机硫化合物与亲核有机金属试剂的交叉偶联反应被称为利贝斯金德 - 斯罗格尔交叉偶联反应。由于起始原料容易获得且反应条件中性，它已成为形成碳 - 碳键的一种有吸引力的方法，特别是在传统方法失败的情况下。自2000年利贝斯金德和斯罗格尔的开创性工作以来，该反应受到了合成领域的高度关注。在这篇专题综述中，我们重点介绍了这种有趣的交叉偶联反应的最新进展及其在有机合成中的应用。