The association between cumulative mean arterial blood pressure (MAP) and risks of adverse cardiac and cerebrovascular events (CCVEs) has not been characterized. This prospective cohort study included 53,813 participants, free of prior myocardial infarction or stroke in or before 2010 (baseline) from a community-based cohort including 101,510 participants. Cumulative MAP was defined as the summed average MAP for each pair of consecutive examinations multiplied by the time interval with the data from previous surveys (2006-2007, 2008 to 2009, 2010-2011). Incident adverse CCVEs were ascertained by both the information collection in biennial follow-up surveys (2012-2013, 2014-2015) and surveying each year's discharge lists from local hospitals and death certificates from state vital statistics offices by three experienced physicians blinded to the study design. The study population were stratified into quartiles based on cumulative MAP (
累积平均动脉血压(MAP)与不良心脑血管事件(CCVEs)风险之间的关联尚未明确。这项前瞻性队列研究纳入了53813名参与者,这些参与者来自一个包含101510名参与者的社区队列,在2010年(基线)或之前没有心肌梗死或中风病史。累积MAP定义为每次连续检查的平均MAP总和乘以与先前调查(2006 - 2007年、2008 - 2009年、2010 - 2011年)数据的时间间隔。不良CCVEs事件是通过两年一次的随访调查(2012 - 2013年、2014 - 2015年)收集信息以及由三名不了解研究设计的经验丰富的医生查阅当地医院每年的出院名单和州生命统计办公室的死亡证明来确定的。研究人群根据累积MAP分为四分位数(