活性氧调控巨噬细胞极化的研究进展

Abstract: Macrophages can be polarized into two phenotypes: classically activated macrophages (M1) and alternatively activated macrophages (M2). The former secretes pro-inflammatory cytokines to promote the inflammatory response, while the latter secretes inflammatory inhibitory factors to inhibit excessive inflammatory response, promote angiogenesis, tissue repair and tumor growth, etc. As an important second messenger, reactive oxygen species (ROS) not only lead to the production of pro-inflammatory cytokines, but also promote the occurrence and development of tumors. Under different stimulation conditions, ROS can regulate the polarization process of macrophages, making them convert to different phenotypes and thus play different roles.

摘要: 巨噬细胞可以极化为两种表型: 经典激活巨噬细胞( M1) 和替代激活巨噬细胞( M2) ， 前者分泌促炎细胞因.子来促进炎性反应，而后者分泌炎性抑制因子抑制过量炎性反应、促进血管生成、组织修复和肿瘤生长等。作为重.要的第二信使，活性氧( ROS) 不仅导致促炎细胞因子的产生， 而且促进肿瘤的发生和发展。在不同刺激条件下，.ROS 可调控巨噬细胞的极化过程，使其向不同表型转换，从而发挥不同作用。