Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension.

Background: Intestinal damage caused by intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) can lead to the ectopic gut microbiota, which can contribute to liver injury via portal veins. Therefore, it is speculated that gut microbiota disorder caused by IAH/ACS may result in liver injury. The relationship between gut microbiota and IAH/ACS-related liver injury was investigated in this study. Methods: A model of IAH was established in rats, and 16S rRNA sequencing was analyzed for gut microbiota in the feces of rats. The elimination of gut microbiota was completed by antibiotics gavage, and fecal microbiota transplantation (FMT) was used to change the composition of gut microbiota in rats. Results: In addition to the traditional cause of liver blood vessel compression, liver injury caused by IAH was also associated with gut microbiota dysbiosis. Gut microbiota clearance can relieve liver injury caused by IAH, while FMT from IAH-intervened rats can aggravate IAH-related liver injury. Conclusion: The gut microbiota was one of the most important factors contributing to the IAH-related liver injury, and the JNK/p38 signaling pathway was activated in this process.

背景：腹内高压（IAH）和腹腔间隔室综合征（ACS）引起的肠道损伤可导致肠道菌群异位，其可通过门静脉导致肝损伤。因此，推测由IAH/ACS引起的肠道菌群失调可能导致肝损伤。本研究探讨了肠道菌群与IAH/ACS相关肝损伤之间的关系。 方法：在大鼠中建立IAH模型，对大鼠粪便中的肠道菌群进行16S rRNA测序分析。通过抗生素灌胃清除肠道菌群，采用粪便菌群移植（FMT）改变大鼠肠道菌群组成。 结果：除了传统的肝血管受压原因外，IAH导致的肝损伤还与肠道菌群失调有关。清除肠道菌群可缓解IAH导致的肝损伤，而来自IAH干预大鼠的FMT会加重IAH相关肝损伤。 结论：肠道菌群是导致IAH相关肝损伤的最重要因素之一，在此过程中JNK/p38信号通路被激活。