Synthesis and CB1 cannabinoid receptor affinity of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles.

A series of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles were synthesized regioselectively using click chemistry and evaluated at CB1 cannabinoid receptors. The n-propyl ester 11 (Ki = 4.6 nM) and phenyl ester 14 Ki = 11 nM) exhibited the most potent affinity of the series.

利用点击化学区域选择性地合成了一系列4 - 烷氧羰基 - 1,5 - 二芳基 - 1,2,3 - 三唑，并在CB1大麻素受体上进行了评估。该系列中，正丙酯11（Ki = 4.6 nM）和苯酯14（Ki = 11 nM）表现出最强的亲和力。